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cinchocaine

D04AB02

Forms & Strengths

Ointment: 0.5%
Cream: 0.5%
Suppositories: 1 mg
Solution: various concentrations for spinal anesthesia (historically)

Adult Dosing

Anorectal conditions: Apply ointment or insert suppository 2-3 times daily, preferably after bowel movements.
Topical pruritus/pain: Apply a thin layer to the affected area up to 3-4 times daily.

Pediatric Dosing

Safety and efficacy in pediatric patients not well established.
Use in children generally discouraged or restricted to lower concentrations with physician guidance.

Indications

Symptomatic relief of pain, pruritus, and discomfort associated with hemorrhoids.
Anal fissures and pruritus ani.
Minor topical skin irritations and insect bites.

Mechanism of Action

Amide-type local anesthetic.
Reversibly stabilizes the neuronal membrane, decreasing its permeability to sodium ions.
Inhibits the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthesia.

Contraindications

Hypersensitivity to cinchocaine (dibucaine) or other amide-type local anesthetics.
Application to severely inflamed, traumatized, or infected mucosa/skin where systemic absorption may be increased.

Adverse Reactions

Local burning, stinging, erythema, or contact dermatitis at the application site.
Hypersensitivity reactions, including angioedema, urticaria, and anaphylaxis.
Systemic toxicity (rare, associated with excessive absorption): CNS excitation/depression, cardiovascular depression.

Drug Interactions

Class III antiarrhythmic drugs (e.g., amiodarone): additive cardiac effects may occur with systemic absorption.
Other local anesthetics: potential for additive toxicity when co-administered.

Curated Content: Needs Vetting Before Put to Clinical Use