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DERMATOLOGICALS › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › Anesthetics for topical use
oxybuprocaine
D04AB03
Adult Dosing
- Surface anesthesia of the eye: 1-2 drops instilled into the conjunctival sac prior to minor procedures (tonometry, foreign body removal, short surgical interventions).
Pediatric Dosing
- Surface anesthesia of the eye: 1 drop instilled into the conjunctival sac as needed for minor diagnostic or surgical procedures, with dosage adjusted by age and clinical response.
Indications
- Topical local anesthesia for diagnostic and surgical ocular procedures
- Tonometry
- Gonioscopy
- Corneal scraping
- Removal of corneal foreign bodies
Mechanism of Action
- Ester-type local anesthetic that reversibly blocks sodium ion channels in nerve membranes, stabilizing the neuronal membrane and preventing the initiation and conduction of nerve impulses in sensory nerve fibers of the eye.
Contraindications
- Hypersensitivity to oxybuprocaine or other ester-type local anesthetics
- History of hypersensitivity to para-aminobenzoic acid (PABA) derivatives or parabens
- Chronic or long-term use (risk of severe corneal damage)
Adverse Reactions
- Transient stinging, burning, and redness upon instillation
- Temporary blurred vision
- Allergic contact dermatitis
- Corneal epithelial keratitis, clouding, or sloughing with prolonged use
- Systemic toxicity (extremely rare, associated with overdose or hypersensitivity)
Drug Interactions
- May inhibit the antibacterial action of sulfonamides
- Potential for additive local anesthetic toxicity with concurrent topical ocular anesthetics
Curated Content: Needs Vetting Before Put to Clinical Use