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DERMATOLOGICALS › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › Anesthetics for topical use
quinisocaine
D04AB05
Forms & Strengths
- Topical ointment 0.5%
- Topical solution 0.5%
Adult Dosing
- Apply sparingly to affected area 2 to 4 times daily as needed for pruritus or pain
- Do not apply to large surface areas or broken/blistered skin to prevent systemic toxicity
Pediatric Dosing
- Safety and efficacy in pediatric patients not established; use with extreme caution if directed by a physician
Indications
- Temporary relief of pain and itching associated with minor skin irritations
- Pruritus ani or vulvae
Mechanism of Action
- Acts as a topical local anesthetic by stabilizing the neuronal membrane
- Inhibits the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthesia
Contraindications
- Hypersensitivity to quinisocaine or other ester-type local anesthetics
- Application to infected, denuded, or severely traumatized skin
Adverse Reactions
- Contact dermatitis
- Local irritation
- Erythema
- Pruritus at application site
- Systemic toxicity (rare, associated with excessive application or broken skin)
Drug Interactions
- Other local anesthetics (additive systemic toxicity)
- Class I antiarrhythmic drugs (potential synergistic cardiac effects if absorbed systemically)
Curated Content: Needs Vetting Before Put to Clinical Use