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DERMATOLOGICALS › ANTIPSORIATICS › ANTIPSORIATICS FOR TOPICAL USE › Antracen derivatives
dithranol
D05AC01
Forms & Strengths
- cream 0.1%, 0.5%, 1%
- ointment 0.1%, 0.5%, 1%, 2%
- solution 1%, 2%
Adult Dosing
- apply 0.1% to 2% solution or cream to affected areas once daily
- increase concentration as needed and tolerated
- typically applied for 30 minutes to several hours before washing off
Pediatric Dosing
- not recommended for children under 6 years
- for children 6-12 years, apply 0.1% to 0.5% solution or cream once daily under close adult supervision
Indications
- treatment of chronic plaque psoriasis
- treatment of other psoriatic dermatoses
Mechanism of Action
- inhibits cell division in the epidermis, reducing scaling and thickening
- anti-proliferative and anti-inflammatory effects on keratinocytes
Contraindications
- hypersensitivity to dithranol or any component of the preparation
- acutely inflamed or raw skin, including exfoliative dermatitis and erythrodermic psoriasis
Adverse Reactions
- skin irritation, including redness, itching, and burning
- stinging sensation, especially in fair-skinned individuals
- rarely, allergic contact dermatitis
Drug Interactions
- may increase the risk of UV radiation damage when used with photo-sensitizing drugs
- avoid concurrent use with other topical irritants or sensitizers
Curated Content: Needs Vetting Before Put to Clinical Use