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DERMATOLOGICALS › ANTIPSORIATICS › ANTIPSORIATICS FOR TOPICAL USE › Other antipsoriatics for topical use
calcipotriol
D05AX02
Forms & Strengths
- Topical cream 0.005%
- Topical ointment 0.005%
- Topical scalp solution 0.005%
Adult Dosing
- Plaque psoriasis: Apply thin layer to affected areas twice daily
- Maximum weekly dose: 100 grams per week
Pediatric Dosing
- Safety and efficacy not established in pediatric patients under 12 years
- Adolescents 12 years and older: Same as adult dosing, limit application to max 30% of body surface area
Indications
- Topical treatment of plaque psoriasis vulgaris in adults and adolescents
Mechanism of Action
- Synthetic vitamin D3 analogue
- Binds to vitamin D receptors in skin cells, inhibiting keratinocyte proliferation and promoting differentiation
- Reduces inflammatory cytokine production in psoriatic plaques
Contraindications
- Hypersensitivity to calcipotriol or any excipient
- Patients with documented disorders of calcium metabolism
- Erythrodermic, exfoliative, or pustular psoriasis
Adverse Reactions
- Skin irritation, burning, stinging, or erythema at application site
- Pruritus and worsening of psoriasis
- Dry skin and dermatitis
- Hypercalcemia and hypercalciuria (with excessive use exceeding maximum weekly dose)
Drug Interactions
- Calcium supplements or thiazide diuretics (increased risk of hypercalcemia)
- Concomitant use with other topical anti-psoriatic drugs on the same site may cause irritation
Curated Content: Needs Vetting Before Put to Clinical Use