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DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › ANTIBIOTICS FOR TOPICAL USE › Other antibiotics for topical use
virginiamycin
D06AX10
Forms & Strengths
- Virginiamycin powder for oral solution
- Virginiamycin 10 mg/g oral powder
- Virginiamycin 20 mg/g oral powder
Adult Dosing
- 25-50 mg/kg/day orally in divided doses
- Not established for human use in many countries, used in veterinary medicine
Pediatric Dosing
- Not established for pediatric use
- Use in children not recommended due to potential risk of aplastic anemia
Indications
- Growth promotion in poultry and swine
- Treatment of bacterial infections in veterinary medicine
Mechanism of Action
- Inhibits protein synthesis in bacteria by binding to the 50S ribosomal subunit
- Interferes with peptide bond formation and translocation
Contraindications
- Hypersensitivity to virginiamycin
- Pregnancy and lactation due to potential harm to fetus or newborn
Adverse Reactions
- Gastrointestinal disturbances
- Allergic reactions
- Aplastic anemia
- Pseudomembranous colitis
Drug Interactions
- Decreased efficacy with concomitant use of erythromycin
- Increased toxicity with concomitant use of other antibiotics
- Interference with laboratory tests for liver function and blood clotting
Curated Content: Needs Vetting Before Put to Clinical Use