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DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › ANTIBIOTICS FOR TOPICAL USE › Other antibiotics for topical use
amikacin
D06AX12
Forms & Strengths
- Injection: 50mg/mL, 100mg/2mL, 250mg/mL
- Vial: 50mg/mL, 100mg/2mL, 500mg/2mL
Adult Dosing
- Typical dose: 15mg/kg/day IV/IM in 2-3 divided doses
- Maximum dose: 1.5g/day
- Dose adjustment for renal impairment: CrCl < 50mL/min, reduce dose
Pediatric Dosing
- Neonates: 15mg/kg/day IV/IM in 2 divided doses
- Infants/Children: 15-20mg/kg/day IV/IM in 2-3 divided doses
- Dose adjustment for pediatric renal impairment: CrCl < 50mL/min, reduce dose
Indications
- Treatment of serious bacterial infections
- Infections caused by gram-negative bacteria
- Sepsis, meningitis, peritonitis, pneumonia, skin and soft tissue infections
Mechanism of Action
- Aminoglycoside antibiotic
- Inhibits protein synthesis by binding to 30S ribosomal subunit
- Bactericidal activity, disrupts cell membrane and causes cell death
Contraindications
- Hypersensitivity to amikacin or other aminoglycosides
- Pregnancy, unless benefits outweigh risks
- Myasthenia gravis, parkinsonism, or other neuromuscular disorders
Adverse Reactions
- Nephrotoxicity, ototoxicity, neuromuscular blockade
- Vestibular toxicity, auditory toxicity, renal impairment
- Rash, fever, headache, dizziness, nausea, vomiting, diarrhea
Drug Interactions
- Nephrotoxic agents: cephalosporins, vancomycin, loop diuretics
- Ototoxic agents: loop diuretics, vancomycin, cisplatin
- Neuromuscular blocking agents: anesthetics, muscle relaxants, succinylcholine
Curated Content: Needs Vetting Before Put to Clinical Use