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DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › ANTIBIOTICS FOR TOPICAL USE › Other antibiotics for topical use
retapamulin
D06AX13
Forms & Strengths
- Topical Ointment: 1% (10 mg/g)
Adult Dosing
- Impetigo: Apply a thin layer to the affected area (up to 100 cm² in adults) twice daily for 5 days
Pediatric Dosing
- Impetigo (Patients aged 9 months and older): Apply a thin layer to the affected area (up to 2% of total body surface area) twice daily for 5 days
Indications
- Treatment of impetigo due to Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes
Mechanism of Action
- Pleuromutilin antibiotic that inhibits bacterial protein synthesis by interacting with the 50S ribosomal subunit, specifically binding to the peptidyl transferase center and protein L3
Contraindications
- History of hypersensitivity to retapamulin or any of the product components
Adverse Reactions
- Application site irritation
- Application site pruritus
- Erythema
- Contact dermatitis
Drug Interactions
- Co-administration of strong CYP3A4 inhibitors (e.g., ketoconazole) may increase systemic exposure of retapamulin if applied over large surface areas
- Avoid concurrent use of other local topical products on the same infected area
Curated Content: Needs Vetting Before Put to Clinical Use