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DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › CHEMOTHERAPEUTICS FOR TOPICAL USE › Sulfonamides
mafenide
D06BA03
Forms & Strengths
- Topical cream: 85 mg/g (8.5%)
Adult Dosing
- Apply topically to burn wounds once or twice daily using a sterile gloved hand to maintain a 1-2 mm thick layer until healing is achieved or grafting is performed.
Pediatric Dosing
- Pediatric patients over 2 months: Apply topically once or twice daily to burn wounds in a 1-2 mm thick layer.
Indications
- Adjunctive treatment of patients with second- and third-degree burns to prevent sepsis and reduce bacterial colonization.
Mechanism of Action
- Sulfonamide derivative that diffuses through avascular tissues; exerts bacteriostatic action against many Gram-negative and Gram-positive bacteria, including Pseudomonas aeruginosa.
Contraindications
- Hypersensitivity to mafenide or any component of the formulation
- Acute sulfonamide hypersensitivity
Adverse Reactions
- Pain or burning sensation at the application site
- Rash and allergic contact dermatitis
- Metabolic acidosis caused by carbonic anhydrase inhibition
- Tachypnea or hyperventilation
Drug Interactions
- Topical carbonic anhydrase inhibitors (e.g., dorzolamide) may increase the risk of systemic metabolic acidosis
- Other topical antimicrobial agents applied to the same site may have antagonistic or synergistic effects
Curated Content: Needs Vetting Before Put to Clinical Use