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DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › CHEMOTHERAPEUTICS FOR TOPICAL USE › Sulfonamides
sulfamethizole
D06BA04
Adult Dosing
- Apply small amount of ointment to affected eye(s) 1 to 3 times daily or as needed for infection
Pediatric Dosing
- Safety and efficacy in pediatric patients under 2 months not established
- Apply to affected eye(s) 1 to 3 times daily for older children
Indications
- Treatment of superficial ocular infections caused by susceptible microorganisms
- Adjuvant treatment in trachoma and inclusion conjunctivitis
Mechanism of Action
- Competitive inhibition of bacterial dihydropteroate synthase
- Blocks synthesis of dihydrofolic acid required for bacterial purine and pyrimidine synthesis
Contraindications
- Hypersensitivity to sulfonamides or any component of the formulation
- Viral or fungal diseases of the cornea and conjunctiva
- Neonates under 2 months of age due to risk of kernicterus
Adverse Reactions
- Transient stinging or burning upon instillation
- Local irritation
- Hypersensitivity reactions including contact dermatitis
- Blurred vision
Drug Interactions
- Local anesthetics containing tetracaine may antagonize antibacterial activity of sulfonamides
- Incompatible with silver preparations in ophthalmic use
Curated Content: Needs Vetting Before Put to Clinical Use