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DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › CHEMOTHERAPEUTICS FOR TOPICAL USE › Sulfonamides
sulfamerazine
D06BA06
Forms & Strengths
- Topical cream: 1%
- Topical ointment: 1%
Adult Dosing
- Apply a thin layer to affected area 1 to 2 times daily
- Duration depends on clinical response and etiology of the lesion
Pediatric Dosing
- Safety and efficacy in pediatric patients under 2 months not established
- Children >2 months: Apply a thin layer 1 to 2 times daily as directed
Indications
- Prevention and treatment of wound infections in second- and third-degree burns
- Adjunctive treatment for local superficial infections of the skin
Mechanism of Action
- Sulfonamide derivative that acts as a competitive inhibitor of dihydropteroate synthase
- Blocks bacterial synthesis of folic acid, inhibiting growth of susceptible gram-positive and gram-negative bacteria
Contraindications
- Hypersensitivity to sulfonamides or any component of the formulation
- History of drug-induced idiosyncratic reactions to sulfonamides
- Premature infants and newborn infants during the first 2 months of life due to risk of kernicterus
- Pregnant women at term
Adverse Reactions
- Local burning, stinging, or pain at application site
- Pruritus and rash
- Allergic contact dermatitis
- Systemic absorption in extensive burns may lead to sulfonamide-associated adverse effects including crystalluria and hypersensitivity reactions
Drug Interactions
- Topical proteolytic enzymes (e.g., collagenase): Sulfonamides may be inactivated by heavy metal derivatives present in enzymatic debridement agents
- Systemic sulfonamide interactions may occur with significant percutaneous absorption
Curated Content: Needs Vetting Before Put to Clinical Use