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DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › CHEMOTHERAPEUTICS FOR TOPICAL USE › Antivirals
tromantadine
D06BB02
Adult Dosing
- Apply a 1 cm strip of gel to the affected skin area up to 5 times daily at the earliest sign of Herpes simplex labialis symptoms (tingling, itching).
Pediatric Dosing
- Safety and efficacy in children have not been extensively established; use with caution.
Indications
- Early treatment of Herpes labialis (cold sores)
Mechanism of Action
- Synthetic antiviral agent that inhibits viral penetration into host cells and alters viral glycoprotein synthesis, preventing cell-to-cell fusion and replication of Herpes simplex virus.
Contraindications
- Hypersensitivity to tromantadine or any excipients in the formulation
- Application to mucous membranes or open, weeping wounds
Adverse Reactions
- Contact dermatitis
- Erythema
- Pruritus
- Burning sensation at the application site
Drug Interactions
- No clinically significant systemic drug interactions reported due to minimal percutaneous absorption
- Avoid simultaneous application of other topical medications on the same skin area to prevent altered absorption or increased irritation
Curated Content: Needs Vetting Before Put to Clinical Use