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lysozyme

D06BB07

Forms & Strengths

Ophthalmic drops: 0.2%
Topical ointment: 1%
Oral lozenges: 5 mg, 10 mg, 20 mg
Nasal spray: 0.5%

Adult Dosing

Ophthalmic: 1-2 drops into the affected eye(s) 3-4 times daily for infectious conjunctivitis
Topical: Apply a thin layer to affected skin areas 2-3 times daily
Oral: 10-20 mg dissolved slowly in the mouth 3-4 times daily for pharyngitis or oral mucosal inflammation

Pediatric Dosing

Children >6 years: Same as adult dosing for oral lozenges and topical formulations
Ophthalmic (pediatric): 1 drop 2-3 times daily under medical supervision

Indications

Adjunctive treatment of superficial bacterial and viral ocular infections
Treatment of inflammatory conditions of the oral cavity and pharynx
Topical management of minor skin wounds, burns, and abrasions

Mechanism of Action

Enzymatically hydrolyzes the beta(1-4) glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in the peptidoglycan cell walls of Gram-positive bacteria
Exerts anti-inflammatory and immunomodulating effects by binding to and neutralizing various bacterial toxins and enhancing phagocytosis

Contraindications

Known hypersensitivity to lysozyme or egg-derived products (due to potential cross-reactivity with egg white lysozyme)
Severe systemic hypersensitivity reactions to the excipients

Adverse Reactions

Transient stinging or burning upon ophthalmic instillation
Local skin irritation, rash, or contact dermatitis with topical use
Rare allergic hypersensitivity reactions including urticaria and pruritus

Drug Interactions

Incompatible with high concentrations of anionic surfactants and strong oxidizing agents
May decrease the local antibacterial efficacy of certain topical penicillins if administered concurrently

Curated Content: Needs Vetting Before Put to Clinical Use