← Search & browse all drugs

fluocortin

D07AB04

Forms & Strengths

Topical cream 0.75%

Adult Dosing

Apply a thin film to the affected area 2 to 3 times daily
Reduce frequency as condition improves
Limit use to continuous periods not exceeding 2-3 weeks

Pediatric Dosing

Safety and efficacy in pediatric patients are not well established
Use with caution in children, applying the minimum effective amount for the shortest possible duration
Avoid use under occlusive dressings

Indications

Inflammatory and pruritic dermatoses responsive to topical corticosteroids
Eczema
Contact dermatitis

Mechanism of Action

Moderate-potency glucocorticoid
Binds to cytosolic glucocorticoid receptors, modulating transcription of anti-inflammatory genes
Inhibits phospholipase A2 via lipocortins, suppressing release of arachidonic acid and subsequent inflammatory mediators

Contraindications

Hypersensitivity to fluocortin or any component of the formulation
Tuberculous, fungal, or viral skin lesions (e.g., herpes simplex, varicella)
Rosacea and perioral dermatitis
Vaccination reactions in the treatment area

Adverse Reactions

Local burning, itching, or irritation
Skin atrophy, striae, and telangiectasia with prolonged use
Hypopigmentation
Secondary skin infections
Systemic absorption leading to hypothalamic-pituitary-adrenal axis suppression with prolonged or occlusive use

Drug Interactions

No significant systemic drug interactions expected with normal topical application
Concurrent use of other topical corticosteroids may increase the risk of adverse effects or systemic absorption
Possible additive skin irritation with keratolytic or abrasive agents

Curated Content: Needs Vetting Before Put to Clinical Use