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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, moderately potent (group II)
triamcinolone
D07AB09
Forms & Strengths
- Cream: 0.1% (1mg/g)
- Ointment: 0.1% (1mg/g)
- Lotion: 0.1% (1mg/g)
- Paste: 0.1% (1mg/g) in Orabase
- Injectable suspension: 10mg/mL, 40mg/mL
- Aerosol inhaler: 100mcg/actuation
Adult Dosing
- Cream/Ointment/Lotion: Apply 2-3 times a day, thin layer
- Paste in Orabase: Apply 2-3 times a day, thin layer
- Injectable suspension: 2.5-5mg for intra-articular/synovial use, repeat as needed
- Aerosol inhaler: 2 inhalations, 2-3 times a day
Pediatric Dosing
- Topical: Apply 2-3 times a day, thin layer, for children >12 years old
- Injectable suspension: Use with caution in children, intra-articular/synovial use 2.5-5mg, repeat as needed
- Aerosol inhaler: For children >12 years old, 2 inhalations, 2 times a day
Indications
- Treatment of dermatoses: atopic dermatitis, contact dermatitis, lichen simplex
- Intra-articular/synovial injection: osteoarthritis, rheumatoid arthritis
- Inhalation: asthma, chronic obstructive pulmonary disease (COPD)
Mechanism of Action
- Corticosteroid, anti-inflammatory
- Acts on HPA axis to reduce inflammation and immune responses
- Induces lipocortin synthesis, inhibiting phospholipase A2 to reduce inflammation
Contraindications
- Hypersensitivity to triamcinolone
- Tuberculosis of the skin
- Fungal or bacterial skin infections (untreated)
- Herpes simplex keratitis, varicella or vaccinia
Adverse Reactions
- Topical: skin atrophy, telangiectasia, striae
- Injectable: flushing, local pain, tendon rupture
- Inhalation: oral thrush, cough, wheezing, shortness of breath
Drug Interactions
- CYP3A4 inhibitors: increase risk of corticosteroid toxicity
- Warfarin: enhance anticoagulant effect
- Salicylates, NSAIDs: increase risk of gastrointestinal ulcers/bleeding
- Vaccines: reduce vaccine efficacy, avoid live vaccines
Curated Content: Needs Vetting Before Put to Clinical Use