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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, potent (group III)
fluclorolone
D07AC02
Forms & Strengths
- Topical cream 0.025%
- Topical ointment 0.025%
Adult Dosing
- Apply thinly to affected area 2 to 3 times daily
- Reduce frequency as condition improves
- Discontinue once control is achieved
Pediatric Dosing
- Safety and efficacy not well established in children
- If used in pediatric patients, use lowest effective dose for shortest possible duration
- Avoid use in occlusive dressings or diaper area
Indications
- Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
- Eczema
- Psoriasis
- Contact dermatitis
Mechanism of Action
- High potency topical fluorinated corticosteroid
- Induces phospholipase A2 inhibitory proteins (lipocortins)
- Suppresses release of arachidonic acid, reducing synthesis of inflammatory prostaglandins and leukotrienes
- Causes vasoconstriction and decreases lymphocyte and macrophage migration
Contraindications
- Hypersensitivity to fluclorolone or any component of the formulation
- Untreated bacterial, fungal, or viral skin infections (e.g., herpes simplex, varicella)
- Rosacea and perioral dermatitis
- Atrophic skin conditions
Adverse Reactions
- Skin atrophy, striae, and telangiectasia
- Burning, stinging, and pruritus at application site
- Folliculitis and acneiform eruptions
- Hypopigmentation
- Systemic absorption leading to HPA axis suppression with prolonged use or occlusion
Drug Interactions
- Concurrent use with other potent topical corticosteroids may increase risk of systemic toxicity
- Cytochrome P450 inhibitors (theoretical risk with high systemic absorption, though minimal clinically)
Curated Content: Needs Vetting Before Put to Clinical Use