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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, potent (group III)
budesonide
D07AC09
Forms & Strengths
- Topical cream 0.025%
- Topical ointment 0.025%
Adult Dosing
- Apply a thin film to the affected skin areas 1 to 2 times daily
- Massage gently until the medication disappears
- Discontinue therapy when control is achieved
Pediatric Dosing
- Apply a thin film to the affected skin areas 1 to 2 times daily for pediatric patients 6 years of age and older
- Use the least amount necessary to achieve effective therapy
- Avoid use in diaper dermatitis
Indications
- Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Mechanism of Action
- Glucocorticoid receptor agonist with high topical anti-inflammatory potency
- Induces phospholipase A2 inhibitory proteins (lipocortins), controlling biosynthesis of potent inflammatory mediators
- Decreases accumulation of macrophages and leukocytes at sites of inflammation
Contraindications
- Hypersensitivity to budesonide or any component of the formulation
- Untreated bacterial, fungal, or viral skin infections
- Rosacea and perioral dermatitis
Adverse Reactions
- Local burning, stinging, and irritation
- Pruritus and dry skin
- Skin atrophy, striae, and telangiectasia
- Hypopigmentation and hypertrichosis
- Systemic absorption leading to HPA axis suppression with prolonged use or occlusive dressings
Drug Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase systemic exposure if significant absorption occurs
- Concomitant immunosuppressive therapies may potentiate local infection risks
Curated Content: Needs Vetting Before Put to Clinical Use