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mometasone

D07AC13

Forms & Strengths

Cream: 0.1%
Ointment: 0.1%
Solution (Lotion): 0.1%

Adult Dosing

Apply a thin film to the affected skin areas once daily.
Do not use with occlusive dressings unless directed by a physician.
Discontinue therapy when control is achieved.

Pediatric Dosing

Children >= 2 years: Apply a thin film to affected areas once daily.
Limit therapy to 2 weeks maximum.
Use restricted to the least amount compatible with an effective therapeutic regimen.

Indications

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Mechanism of Action

Induces lipocortins (annexins) which inhibit phospholipase A2, reducing synthesis of inflammatory mediators like prostaglandins and leukotrienes.
Provides anti-inflammatory, antipruritic, and vasoconstrictive properties.

Contraindications

Hypersensitivity to mometasone furoate or other corticosteroids.
Rosacea and perioral dermatitis.
Primary cutaneous viral, fungal, or bacterial infections.

Adverse Reactions

Burning, pruritus, and stinging at application site.
Skin atrophy, striae, and telangiectasia with prolonged use.
Hypopigmentation and hypertrichosis.
Systemic absorption leading to HPA axis suppression.

Drug Interactions

Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase systemic exposure if absorbed significantly.
Concomitant use with other systemic or topical corticosteroids may potentiate immunosuppressive and adverse effects.

Curated Content: Needs Vetting Before Put to Clinical Use