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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, potent (group III)
hydrocortisone aceponate
D07AC16
Forms & Strengths
- cream 0.1273% w/w
- ointment 0.1273% w/w
Adult Dosing
- apply a thin layer to affected area 1-2 times daily
- do not use for more than 12 weeks
Pediatric Dosing
- apply a thin layer to affected area 1 time daily for children over 6 years old
- use for children under 6 years old only under medical supervision
Indications
- atopic dermatitis
- eczema
- contact dermatitis
- skin inflammation and pruritus
Mechanism of Action
- inhibits inflammatory reactions and immune responses
- reduces pruritus and skin inflammation
- modulates T-cell activation and cytokine production
Contraindications
- hypersensitivity to hydrocortisone aceponate or any excipients
- skin infections (bacterial, fungal, or viral)
- acne vulgaris
- perianal and genital areas irritation
Adverse Reactions
- burning sensation
- itching
- redness
- skin atrophy
- telangiectasia
- hypopigmentation
Drug Interactions
- corticosteroids may interact with anticoagulants and increase INR
- CYP3A4 inhibitors may increase levels of hydrocortisone aceponate
- concomitant use of other corticosteroids may increase risk of adverse effects
Curated Content: Needs Vetting Before Put to Clinical Use