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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, potent (group III)
fluticasone
D07AC17
Forms & Strengths
- Nasal spray 50 mcg/actuation
- Nasal spray 100 mcg/actuation
- Nasal spray 200 mcg/actuation
- Topical cream 0.005%
- Topical ointment 0.005%
- Inhalation powder 50 mcg/inhalation
- Inhalation powder 100 mcg/inhalation
- Inhalation powder 200 mcg/inhalation
- Inhalation powder 250 mcg/inhalation
- Inhalation powder 500 mcg/inhalation
Adult Dosing
- Allergic rhinitis: 2 sprays (50 mcg/spray) per nostril once daily
- Nasal polyps: 2 sprays (50 mcg/spray) per nostril twice daily
- Asthma: 1-2 inhalations (50-100 mcg/inhalation) twice daily
- Skin conditions: apply topical cream or ointment once or twice daily
Pediatric Dosing
- Allergic rhinitis (4-11 years): 1 spray (50 mcg/spray) per nostril once daily
- Asthma (4-11 years): 1 inhalation (50 mcg/inhalation) twice daily
- Skin conditions (3 months and older): apply topical cream or ointment once or twice daily
Indications
- Allergic rhinitis
- Nasal polyps
- Asthma
- Atopic dermatitis
- Eczema
- Psoriasis
- Skin allergies
Mechanism of Action
- Glucocorticoid receptor agonist
- Inhibits inflammatory cell infiltration
- Reduces pro-inflammatory cytokine production
Contraindications
- Hypersensitivity to fluticasone or any component
- Untreated fungal, bacterial, or viral infections
- Rosacea, acne, or perioral dermatitis
Adverse Reactions
- Headache
- Nasal congestion
- Sore throat
- Cough
- Skin irritation
- Pruritus
- Hoarseness
Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may increase fluticasone levels
- Hepatic enzyme inducers (e.g., phenobarbital, phenytoin): may decrease fluticasone levels
- Other glucocorticoids: may increase risk of systemic effects
Curated Content: Needs Vetting Before Put to Clinical Use