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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, very potent (group IV)
halcinonide
D07AD02
Forms & Strengths
- Cream: 0.1%
- Ointment: 0.1%
- Topical solution: 0.1%
Adult Dosing
- Apply a thin film to affected areas 2-3 times daily
- Not for oral, intravenous, or intraocular use
Pediatric Dosing
- Avoid use in children under 12 years old due to potential adrenal suppression
- Use with caution in children 12 years and older
Indications
- Corticosteroid-responsive dermatoses
- Atopic dermatitis
- Seborrheic dermatitis
- Psoriasis
- Eczematous dermatitis
Mechanism of Action
- Inhibits inflammation and immune response by suppressing the migration of leukocytes
- Stabilizes lysosomal membranes and prevents the release of destructive enzymes
- Induces the synthesis of lipocortins which inhibit the production of pro-inflammatory eicosanoids
Contraindications
- Hypersensitivity to halcinonide or other corticosteroids
- Viral infections (e.g. herpes simplex, varicella, vaccinia)
- Bacterial or fungal infections of the skin (unless accompanied by a suitable anti-infective agent)
Adverse Reactions
- Local irritation
- Pruritus
- Burning
- Skin dryness
- Hypopigmentation
- Hypertension
- Glaucoma (with ocular exposure)
- Hypothalamic-pituitary-adrenal axis suppression
Drug Interactions
- Increased risk of glaucoma with concomitant use of other corticosteroids (e.g. oral, intraocular, or other topical)
- Possible interaction with CYP3A4 inhibitors (e.g. ketoconazole, grapefruit juice)
Curated Content: Needs Vetting Before Put to Clinical Use