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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS › Corticosteroids, moderately potent, combinations with antibiotics
dexamethasone and antibiotics
D07CB04
Forms & Strengths
- Tablets: 0.5mg, 0.75mg, 1mg, 1.5mg, 2mg, 4mg, 6mg
- Oral solution: 0.5mg/5mL, 1mg/5mL
- Injectable solution: 4mg/mL, 10mg/mL
- Topical cream/ointment: 0.1%
Adult Dosing
- Allergic reactions: 4-8mg/day
- Asthma: 4-12mg/day
- Rheumatic disorders: 0.5-9mg/day
- Cancer: 2-40mg/day
- Cerebral edema: 10mg IV, then 4mg IV q6h
Pediatric Dosing
- Allergic reactions: 0.02-0.3mg/kg/day
- Asthma: 0.08-0.3mg/kg/day
- Rheumatic disorders: 0.02-0.15mg/kg/day
Indications
- Allergic reactions
- Anaphylaxis
- Asthma
- Rheumatoid arthritis
- Psoriatic arthritis
- Cancer
- Cerebral edema
- Infections (in combination with antibiotics)
Mechanism of Action
- Glucocorticoid receptor agonist
- Suppresses inflammation and immune responses
- Inhibits phospholipase A2 and COX-2 enzymes
- Stabilizes mast cell membranes
Contraindications
- Hypersensitivity to dexamethasone or other corticosteroids
- Intrathecal administration
- Cerebral malaria
- Fungal infections (unless used in combination with antifungal agents)
- Systemic infections (unless used in combination with antibiotics)
Adverse Reactions
- Weight gain
- Moon face
- Hirsutism
- Acne
- Hypertension
- Glucose intolerance
- Osteoporosis
- Myopathy
- Increased risk of infections
Drug Interactions
- Increased risk of GI bleeding with NSAIDs
- Enhanced hypokalemia with diuretics
- Increased risk of osteoporosis with anticonvulsants
- Decreased effectiveness of dexamethasone with barbiturates
- Increased risk of infections with live vaccines
Curated Content: Needs Vetting Before Put to Clinical Use