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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS › Corticosteroids, potent, combinations with antibiotics
fluocinolone acetonide and antibiotics
D07CC02
Forms & Strengths
- Topical cream 0.01% with neomycin 0.5% and polymyxin B sulfate 10,000 units/g
- Topical ointment 0.025% with neomycin 0.5% and polymyxin B sulfate 10,000 units/g
Adult Dosing
- Apply thin film to affected area 2-4 times a day
- Discontinue when control is achieved, taper as needed
- Do not use for more than 8 weeks
Pediatric Dosing
- Apply thin film to affected area 2-4 times a day for children > 2 years
- Not recommended for children < 2 years
- Do not use for more than 4 weeks in pediatric patients
Indications
- Treatment of inflammatory dermatoses
- Eczema, atopic dermatitis, contact dermatitis
- Seborrheic dermatitis, nummular dermatitis
- Secondarily infected skin conditions
Mechanism of Action
- Fluocinolone acetonide: glucocorticoid, anti-inflammatory effects
- Neomycin and polymyxin B sulfate: antibacterial effects by inhibiting protein synthesis
Contraindications
- Hypersensitivity to fluocinolone acetonide or antibiotics
- Viral skin infections, including varicella and herpes simplex
- Fungal or tubercular skin infections
- Rosacea, acne, or perioral dermatitis
Adverse Reactions
- Local irritation, burning, itching, or stinging
- Allergic contact dermatitis, skin atrophy
- Telangiectasias, miliaria, hypopigmentation or hyperpigmentation
- Systemic absorption may cause Cushing's syndrome, hyperglycemia, or glucosuria
Drug Interactions
- Antidiabetics, monitor blood glucose levels
- CYP3A4 inhibitors, may increase fluocinolone acetonide levels
- Live or attenuated vaccines, may decrease response
- Other corticosteroids or immunosuppressants, may increase adverse effects
Curated Content: Needs Vetting Before Put to Clinical Use