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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS › Corticosteroids, potent, combinations with antibiotics
beclometasone and antibiotics
D07CC04
Forms & Strengths
- Cream: 0.025% beclometasone dipropionate with 0.25% neomycin sulfate
- Ointment: 0.025% beclometasone dipropionate with 0.25% neomycin sulfate
- Lotion: not commonly available
Adult Dosing
- Apply thinly 2-3 times a day to affected area
- Not recommended for more than 5 days for facial skin due to risk of rebound effect
- Maximum 30g/week for other areas
Pediatric Dosing
- Avoid in children under 1 year of age
- Apply thinly 1-2 times a day to affected area in children over 1 year old
- Use for shortest duration necessary, not exceeding 5 days on facial skin
Indications
- Severe inflammatory skin conditions unresponsive to less potent corticosteroids
- Infections of the skin where a corticosteroid and antibiotic are required
- Eczema/dermatitis with secondary infection
Mechanism of Action
- Beclometasone: inhibits inflammatory response through vasoconstriction and decreased permeability
- Antibiotics: inhibit bacterial growth through disruption of cell wall synthesis or protein synthesis
- Synergistic effect of corticosteroid and antibiotic to reduce inflammation and clear infection
Contraindications
- Hypersensitivity to beclometasone or neomycin
- Untreated fungal, viral, or tubercular skin infections
- Perioral dermatitis, acne, and rosacea
Adverse Reactions
- Local irritation, itching, redness, or burning
- Allergic contact dermatitis
- Skin atrophy, telangiectasia with prolonged use
Drug Interactions
- Other corticosteroids may increase risk of systemic effects
- Concomitant use with other antibiotics may increase risk of toxicity
- Interactions with vaccines: live vaccines may be less effective, inactivated vaccines are generally safe
Curated Content: Needs Vetting Before Put to Clinical Use