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DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS › Corticosteroids, potent, combinations with antibiotics
fluocinonide and antibiotics
D07CC05
Forms & Strengths
- Cream: fluocinonide 0.1%, neomycin 0.5%, polymyxin B 10,000 units/g
- Ointment: fluocinonide 0.1%, neomycin 0.5%, polymyxin B 10,000 units/g
Adult Dosing
- Apply a thin layer to affected area 2-4 times a day
- Use for a maximum of 2 weeks
Pediatric Dosing
- Apply a thin layer to affected area 2-4 times a day for children over 1 year old
- Use for a maximum of 2 weeks
Indications
- Treatment of bacterial skin infections and eczema
- Relief of inflammation and pruritus in conditions such as psoriasis, dermatitis, and eczema
Mechanism of Action
- Fluocinonide: anti-inflammatory, immunosuppressive effects by inhibiting the production of multiple pro-inflammatory cytokines
- Neomycin: aminoglycoside antibacterial, works by disrupting bacterial DNA and protein synthesis
- Polymyxin B: cationic detergent antibacterial, works by disrupting bacterial cell membranes
Contraindications
- Hypersensitivity to fluocinonide, neomycin, or polymyxin B
- Viral infections (e.g. herpes simplex, varicella, vaccinia)
- Tuberculosis of the skin
Adverse Reactions
- Hypersensitivity reactions (e.g. contact dermatitis, itching, redness)
- Local irritation or burning
- Systemic absorption may cause Cushing's syndrome or adrenal suppression with prolonged use
Drug Interactions
- Use with other corticosteroids may increase the risk of adverse effects
- Concurrent use with aminoglycosides (e.g. neomycin) may increase the risk of nephrotoxicity
Curated Content: Needs Vetting Before Put to Clinical Use