← Search & browse all drugs
DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, OTHER COMBINATIONS › Corticosteroids, weak, other combinations
hydrocortisone
D07XA01
Forms & Strengths
- Cream: 0.1%, 0.5%, 1%, 2.5%
- Ointment: 0.1%, 0.5%, 1%
- Lotion: 0.1%, 0.5%, 1%
- Tablets: 5mg, 10mg, 20mg
- Injection: 25mg, 50mg, 100mg
Adult Dosing
- Allergic reactions: 20-240mg/day PO
- Adrenal insufficiency: 20-30mg/day PO
- Dermatologic disorders: apply topical 1-4 times/day
- Severe inflammation: 100-500mg IM/IV
Pediatric Dosing
- Allergic reactions: 1-4mg/kg/day PO
- Adrenal insufficiency: 10-20mg/m2/day PO
- Dermatologic disorders: apply topical 1-4 times/day
- Severe inflammation: 1-5mg/kg IM/IV
Indications
- Adrenal insufficiency
- Allergic reactions
- Anaphylaxis
- Asthma
- Atopic dermatitis
- Autoimmune disorders
- Inflammatory bowel disease
- Rheumatoid arthritis
- Severe inflammation
Mechanism of Action
- Binds to glucocorticoid receptors
- Inhibits inflammatory gene expression
- Suppresses immune response
- Induces anti-inflammatory genes
Contraindications
- Hypersensitivity to hydrocortisone
- Live or attenuated vaccines
- Systemic fungal infections
Adverse Reactions
- Cushing's syndrome
- Glaucoma
- Hyperglycemia
- Hypertension
- Insomnia
- Moon face
- Muscle weakness
- Osteoporosis
- Weight gain
Drug Interactions
- Barbiturates: decreased corticosteroid levels
- Cyclosporine: increased risk of seizures
- Insulin: increased glucose levels
- Phenytoin: decreased corticosteroid levels
- Rifampin: decreased corticosteroid levels
- Warfarin: increased INR
Curated Content: Needs Vetting Before Put to Clinical Use