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hexamidine

D08AC04

Forms & Strengths

Topical solution (diisethionate salt)
Ophthalmic drops (diisethionate salt, often combined with other antiseptics)
Topical cream/powder

Adult Dosing

Topical solution: Apply undiluted to affected skin areas 2 to 3 times daily.
Ophthalmic: 1-2 drops in the affected eye(s) up to 4 times daily as needed.

Pediatric Dosing

Topical solution: Apply to affected skin areas 2 to 3 times daily (safety and efficacy profile similar to adults for minor cutaneous uses).
Ophthalmic: 1-2 drops in the affected eye(s) up to 4 times daily under medical supervision.

Indications

Antiseptic treatment of minor skin infections and superficial wounds
Disinfection of minor burns and abrasions
Adjuvant treatment of superficial ocular infections (conjunctivitis, keratitis)

Mechanism of Action

Cationic diamidine antiseptic agent that acts against a wide range of gram-positive and gram-negative bacteria
Exerts antimicrobial effects by binding to the negatively charged cell membranes of microorganisms, causing disruption, leakage of intracellular constituents, and cell death

Contraindications

Hypersensitivity to hexamidine or other diamidine derivatives
Avoid prolonged or large-area application on broken skin to prevent systemic absorption

Adverse Reactions

Local skin irritation, burning, or stinging at the application site
Contact dermatitis and allergic hypersensitivity reactions
Transient ocular irritation or stinging when used ophthalmically

Drug Interactions

Avoid simultaneous application of multiple topical antiseptics or soaps on the same area to prevent chemical inactivation or enhanced skin irritation
No significant systemic drug interactions documented due to minimal percutaneous absorption under normal usage

Curated Content: Needs Vetting Before Put to Clinical Use