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DERMATOLOGICALS › ANTISEPTICS AND DISINFECTANTS › ANTISEPTICS AND DISINFECTANTS › Iodine products
iodine
D08AG03
Forms & Strengths
- Iodine topical solution 2%
- Iodine topical tincture 2%
- Iodine topical scrub 7.5%
- Povidone-iodine topical solution 5-10%
- Povidone-iodine topical scrub 7.5-10%
Adult Dosing
- Topical skin disinfection: 1-2% solution, apply as needed
- Preoperative skin preparation: 7.5% scrub, apply 1-2 times
- Wound care: 1-2% solution, apply as needed
Pediatric Dosing
- Topical skin disinfection: 1% solution, apply as needed, for children > 2 years
- Preoperative skin preparation: not recommended for children < 2 years
- Neonatal skin care: 0.5-1% solution, apply as needed, under medical supervision
Indications
- Skin disinfection
- Preoperative skin preparation
- Wound care
- Treatment of iodine deficiency
- Radiographic contrast media
Mechanism of Action
- Disrupts microbial cell membranes
- Inhibits protein synthesis
- Interferes with DNA replication
- Provides antioxidant effects
Contraindications
- Hypersensitivity to iodine
- Iodine-induced thyroid dysfunction
- Pregnancy, especially during the first trimester
- Breastfeeding, due to risk of neonatal thyroid dysfunction
Adverse Reactions
- Skin irritation
- Allergic contact dermatitis
- Thyroid dysfunction
- Metallic taste
- Gastrointestinal upset
Drug Interactions
- Lithium: increased risk of hypothyroidism
- Warfarin: increased anticoagulant effect
- Amiodarone: increased risk of thyroid dysfunction
- Radiographic contrast media: potential for additive effects
Curated Content: Needs Vetting Before Put to Clinical Use