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DERMATOLOGICALS › ANTISEPTICS AND DISINFECTANTS › ANTISEPTICS AND DISINFECTANTS › Quinoline derivatives
clioquinol
D08AH30
Forms & Strengths
- Topical cream 3%
- Topical ointment 3%
Adult Dosing
- Apply thinly to affected area 2 to 3 times daily
- Limit treatment duration to 7 to 14 days to minimize systemic absorption
Pediatric Dosing
- Children > 2 years: Apply thinly to affected area 2 to 3 times daily
- Avoid use in infants and young children due to risk of systemic toxicity and neurotoxicity
Indications
- Treatment of superficial fungal skin infections (e.g., tinea corporis, tinea cruris)
- Treatment of infected eczematoid dermatitis
Mechanism of Action
- Halogenated hydroxyquinoline with antifungal, antibacterial, and antiprotozoal properties
- Chelates trace metals essential for microbial growth and enzyme function
Contraindications
- Hypersensitivity to clioquinol, iodine, or hydroxyquinolines
- Tuberculosis, vaccinia, varicella, and other viral skin lesions
- Use in the eyes or mucous membranes
- Diaper dermatitis in infants
Adverse Reactions
- Local skin irritation, burning, or pruritus
- Allergic contact dermatitis
- Staining of skin, hair, and clothing (yellowish)
- Systemic absorption leading to thyroid function test interferences
Drug Interactions
- Interferes with thyroid function tests (protein-bound iodine levels may be elevated)
- Avoid concurrent use of other topical agents on the same skin area to prevent interaction or increased absorption
Curated Content: Needs Vetting Before Put to Clinical Use