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DERMATOLOGICALS › ANTISEPTICS AND DISINFECTANTS › ANTISEPTICS AND DISINFECTANTS › Quaternary ammonium compounds
cetylpyridinium
D08AJ03
Forms & Strengths
- Lozenges: 1.4 mg, 1.5 mg
- Mouthwash: 0.05%, 0.075%, 0.1%
- Oral Spray: 0.1%
Adult Dosing
- Mouthwash: Rinse with 10-15 mL of undiluted solution for 30-60 seconds up to 3-4 times daily.
- Lozenges: Dissolve 1 lozenge slowly in the mouth every 2-3 hours as needed, not to exceed 8 lozenges per day.
Pediatric Dosing
- Children < 6 years: Not recommended due to risk of swallowing and lack of safety data.
- Children >= 6 years: Same as adult dosing for lozenges and mouthwash under adult supervision.
Indications
- Temporary relief of minor sore throat and minor mouth or throat irritation.
- Reduction of dental plaque and gingivitis.
- Oral hygiene maintenance.
Mechanism of Action
- Cationic quaternary ammonium antiseptic compound.
- Binds to bacterial cell membranes, causing leakage of intracellular constituents, cell lysis, and death.
- Effective against a broad spectrum of Gram-positive pathogens and some fungi.
Contraindications
- Hypersensitivity to cetylpyridinium chloride or any component of the formulation.
- Children under 6 years of age for lozenge use (choking hazard and swallowing risk).
Adverse Reactions
- Mild local irritation of the oral mucosa
- Staining of teeth with prolonged, frequent use
- Transient alteration in taste perception
- Allergic contact dermatitis (rare)
Drug Interactions
- Anionic compounds (e.g., sodium lauryl sulfate found in standard toothpastes) can inactivate the antimicrobial activity of cetylpyridinium; rinse mouth with water before use if brushing with standard toothpaste.
Curated Content: Needs Vetting Before Put to Clinical Use