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hydrogen peroxide

D08AX01

Forms & Strengths

Topical solution 3%
Topical solution 6%

Adult Dosing

Minor cuts and abrasions: Apply small amount to affected area 1 to 4 times daily as needed
Oral debriding agent: Rinse with diluted solution (1:1 with water) up to 4 times daily after meals and at bedtime for up to 7 days

Pediatric Dosing

Children >2 years: Minor cuts and abrasions, apply to affected area 1 to 4 times daily
Children >12 years: Oral rinse, use diluted solution up to 4 times daily

Indications

First-aid antiseptic for minor cuts, scrapes, and burns
Oral mucosal inflammation and minor mouth irritations as a debriding agent/mouthwash

Mechanism of Action

Acts as a topical anti-infective and debriding agent via release of nascent oxygen upon contact with catalase and peroxidases present in tissue and blood
Oxidizing effect causes denaturation of microbial proteins and mechanical cleansing via effervescence

Contraindications

Hypersensitivity to hydrogen peroxide
Do not use in deep or puncture wounds
Do not use in severe burns
Not for use in body cavities or enclosed pockets where oxygen gas release cannot escape (risk of gas embolism)

Adverse Reactions

Local irritation
Stinging or burning upon application
Tissue whitening (bleaching) with higher concentrations
Oral mucosal irritation or hyperkeratosis with prolonged use

Drug Interactions

Inactivated by reducing agents, organic matter, and certain metals (e.g., iodine, permanganates)
May decrease efficacy of other topical antiseptics when used concurrently

Curated Content: Needs Vetting Before Put to Clinical Use