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DERMATOLOGICALS › MEDICATED DRESSINGS › MEDICATED DRESSINGS › Medicated dressings with antiinfectives
nitrofural
D09AA03
Forms & Strengths
- cream 2%
- ointment 2%
- suppository 30mg
- suspension 25mg/5mL
Adult Dosing
- apply topically 2-3 times daily
- 1 suppository at bedtime for 7-10 days
- 25-50mg orally 4 times daily
Pediatric Dosing
- apply topically 2-3 times daily for children >12 years
- 1/2 suppository at bedtime for children 6-12 years for 7-10 days
- 12.5-25mg orally 4 times daily for children 5-12 years
Indications
- burn wound infections
- infected decubitus ulcers
- infected wounds
- urinary tract infections
Mechanism of Action
- inhibits bacterial enzymes
- interferes with DNA and protein synthesis
- nitrofuran derivative with broad antibacterial spectrum
Contraindications
- hypersensitivity to nitrofurans
- glomerulonephritis
- hepatic dysfunction
- pregnancy at term
Adverse Reactions
- allergic reactions
- cyanosis
- diarrhea
- discoloration of teeth and urine
- hemolytic anemia
- hypersensitivity pneumonitis
- neuropathy
- rash
Drug Interactions
- antacids reduce absorption
- probencid increases serum concentrations
- urine discoloration with ascorbic acid
Curated Content: Needs Vetting Before Put to Clinical Use