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triclosan

D09AA06

Forms & Strengths

antibacterial soap 1%
deodorant 0.1-0.3%
toothpaste 0.3%
cosmetic products 0.1-1.0%

Adult Dosing

apply topically as needed
usual concentration 0.1-1.0%
not for oral ingestion

Pediatric Dosing

same as adult dosing for topical use
avoid use in children under 2 years old
consult pediatrician for toothpaste use under 6 years

Indications

skin disinfection
prevention of plaque and gingivitis
deodorizing
personal hygiene products

Mechanism of Action

inhibits enoyl-acyl carrier protein reductase
disrupts bacterial cell membrane synthesis
effective against gram-positive and some gram-negative bacteria

Contraindications

hypersensitivity to triclosan
allergic contact dermatitis
avoid use in patients with active thyroid disorders

Adverse Reactions

skin irritation
allergic contact dermatitis
endocrine disruption
potential impact on thyroid hormones

Drug Interactions

may increase risk of methemoglobinemia with prilocaine
potential interaction with blood thinners
avoid concurrent use with other antibacterial agents

Curated Content: Needs Vetting Before Put to Clinical Use