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fluorometholone

D10AA01

Forms & Strengths

Ophthalmic suspension 0.1%
Ophthalmic suspension 0.25%

Adult Dosing

Instill 1 to 2 drops into the conjunctival sac 2 to 4 times daily
May be increased to every 2 hours during the initial 24 to 48 hours for severe inflammation

Pediatric Dosing

Safety and efficacy in pediatric patients below 2 years of age have not been established
Children 2 years and older: Instill 1 to 2 drops into the conjunctival sac 2 to 4 times daily

Indications

Treatment of corticosteroid-responsive inflammation of the palpal and bulbar conjunctiva, cornea, and anterior segment of the globe

Mechanism of Action

Glucocorticoid that suppresses the inflammatory response to a variety of agents, inhibiting edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, and scar formation

Contraindications

Most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
Mycobacterial infection of the eye
Fungal diseases of ocular structures
Hypersensitivity to any component of the formulation

Adverse Reactions

Elevation of intraocular pressure with possible development of glaucoma
Posterior subcapsular cataract formation
Delayed wound healing
Secondary ocular infection from pathogens including herpes simplex and fungi
Stinging and burning upon instillation

Drug Interactions

Prolonged concurrent use of topical ophthalmic corticosteroids and topical NSAIDs may delay corneal wound healing
Anticholinergics may increase intraocular pressure when used concomitantly

Curated Content: Needs Vetting Before Put to Clinical Use