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DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Corticosteroids, combinations for treatment of acne
methylprednisolone
D10AA02
Forms & Strengths
- Tablets: 2mg, 4mg, 8mg, 16mg, 32mg
- Injection: 20mg/mL, 40mg/mL, 80mg/mL
- Oral solution: 5mg/5mL
Adult Dosing
- Allergic reactions: 4-48mg/day, divided
- Asthma: 4-48mg/day, divided
- Rheumatoid arthritis: 4-16mg/day, divided
- Severe psoriasis: 4-16mg/day, divided
Pediatric Dosing
- Allergic reactions: 0.5-2mg/kg/day, divided
- Asthma: 0.5-2mg/kg/day, divided
- Juvenile rheumatoid arthritis: 0.5-1.7mg/kg/day, divided
Indications
- Allergic reactions
- Asthma
- Rheumatoid arthritis
- Severe psoriasis
- Anaphylaxis
- Bullous pemphigoid
- Immune thrombocytopenia
- Neutrophilia
Mechanism of Action
- Corticosteroid
- Inhibits inflammatory cell activation
- Suppresses immune response
- Induces lipocortin to inhibit phospholipase A2
Contraindications
- Hypersensitivity to methylprednisolone
- Intramuscular injection in idiopathic thrombocytopenic purpura
- Live vaccine administration during treatment
- Systemic fungal infections
Adverse Reactions
- Cushingoid features
- Weight gain
- Hypertension
- Peptic ulcer disease
- Glaucoma
- Osteoporosis
- Hyperglycemia
- Increased risk of infections
Drug Interactions
- Barbiturates: decrease methylprednisolone effect
- Ketoconazole: increase methylprednisolone effect
- Rifampin: decrease methylprednisolone effect
- Cyclosporine: increase risk of seizures
- Macrolide antibiotics: increase methylprednisolone effect
Curated Content: Needs Vetting Before Put to Clinical Use