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DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Retinoids for topical use in acne
motretinide
D10AD05
Forms & Strengths
- 10mg capsule
- 20mg capsule
- 30mg capsule
Adult Dosing
- Initial dose 20-30mg daily
- Maximum dose 60mg daily
- Dose adjustment based on response and tolerance
Pediatric Dosing
- Safety and efficacy not established in children under 12 years of age
Indications
- Treatment of severe acne
- Treatment of acne conglobata
- Treatment of recalcitrant acne
Mechanism of Action
- Selective retinoid receptor agonist
- Inhibits sebum production
- Reduces inflammatory response
Contraindications
- Pregnancy and lactation
- Hypersensitivity to motretinide or other retinoids
- Severe liver or kidney disease
Adverse Reactions
- Dry skin and mucous membranes
- Cheilitis
- Photosensitivity
- Increased liver enzymes
- Bone pain
- Headache
- Fatigue
Drug Interactions
- Concomitant use with tetracyclines increases risk of intracranial hypertension
- Concomitant use with vitamin A supplements increases risk of hypervitaminosis A
- Concomitant use with certain anticonvulsants may decrease motretinide efficacy
Curated Content: Needs Vetting Before Put to Clinical Use