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DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Antiinfectives for treatment of acne
erythromycin
D10AF02
Forms & Strengths
- Tablets: 250mg, 333mg, 500mg
- Capsules: 250mg, 500mg
- Oral suspension: 250mg/5mL, 500mg/5mL
- IV solution: 500mg, 1g
Adult Dosing
- Community-acquired pneumonia: 250-500mg q6h
- Legionnaires disease: 1-2g IV q6h
- Chlamydia: 500mg q6h for 7-14 days
- Acne: 250-500mg q6h for 6-12 weeks
Pediatric Dosing
- Otitis media: 30-50mg/kg/day divided q6h
- Pharyngitis: 30-50mg/kg/day divided q6h
- Pneumonia: 30-50mg/kg/day divided q6h
Indications
- Bacterial infections (e.g. pneumonia, Legionnaires disease, Chlamydia)
- Acne
- Gastric motility disorders
- Eradication of H. pylori
Mechanism of Action
- Macrolide antibiotic
- Inhibits bacterial protein synthesis
- Binds to 50S ribosomal subunit
- Suppresses polypeptide chain elongation
Contraindications
- Hypersensitivity to erythromycin
- Concomitant use with astemizole or terfenadine
- Concomitant use with cisapride
- Liver dysfunction
Adverse Reactions
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Cardiac effects (QT prolongation, arrhythmias)
- Hepatotoxicity
- Rash, urticaria, allergic reactions
Drug Interactions
- Theophylline (increased theophylline levels)
- Warfarin (increased INR)
- Astemizole, terfenadine (cardiac arrhythmias)
- Cisapride (cardiac arrhythmias)
- Digoxin (increased digoxin levels)
Curated Content: Needs Vetting Before Put to Clinical Use