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DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Antiinfectives for treatment of acne
meclocycline
D10AF04
Forms & Strengths
- Capsules: 150mg, 300mg
- Tablets: 150mg, 300mg
Adult Dosing
- Acne: 150-300mg orally every 6 hours
- Rosacea: 150-300mg orally every 6 hours
- Mild to moderate infections: 150-300mg orally every 6 hours
- Severe infections: 300mg orally every 6 hours
Pediatric Dosing
- 8-12 years: 7.5-10mg/kg/day orally divided every 6 hours
- Above 12 years: adult dose
Indications
- Acne
- Rosacea
- Mild to moderate infections
- Severe infections
Mechanism of Action
- Inhibits protein synthesis by binding to 30S ribosomal subunit
- Exhibits bacteriostatic activity against a wide range of gram-positive and gram-negative bacteria
Contraindications
- Hypersensitivity to meclocycline or other tetracyclines
- Children under 8 years
- Pregnancy
- Lactation
Adverse Reactions
- Gastrointestinal upset
- Nausea
- Vomiting
- Diarrhea
- Photosensitivity
- Hepatotoxicity
- Rash
Drug Interactions
- Decreased absorption with antacids, calcium, magnesium, and iron supplements
- Increased toxicity with methoxyflurane
- Increased risk of pseudomembranous colitis with other antibiotics
- Increased theophylline levels
Curated Content: Needs Vetting Before Put to Clinical Use