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DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Antiinfectives for treatment of acne
erythromycin, combinations
D10AF52
Forms & Strengths
- Topical gel: Erythromycin 3% / Benzoyl Peroxide 5%
- Topical gel: Erythromycin 4% / Zinc Acetate 1.2%
Adult Dosing
- Acne vulgaris: Apply a thin film to affected areas twice daily after washing.
Pediatric Dosing
- Acne vulgaris (adolescents >= 12 years): Apply a thin film to affected areas twice daily.
Indications
- Topical treatment of acne vulgaris
Mechanism of Action
- Erythromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.
- Benzoyl peroxide provides keratolytic and bactericidal effects against Cutibacterium acnes.
- Zinc acetate reduces inflammatory lesions and sebum secretion.
Contraindications
- Hypersensitivity to erythromycin, benzoyl peroxide, zinc, or any component of the formulation
- History of antibiotic-associated colitis or regional enteritis
Adverse Reactions
- Dry skin
- Erythema
- Burning sensation
- Pruritus
- Peeling
- Contact dermatitis
Drug Interactions
- Concomitant topical acne therapies (may cause cumulative irritant or drying effects)
- Antagonism may occur with concurrent use of topical clindamycin and erythromycin
Curated Content: Needs Vetting Before Put to Clinical Use