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resorcinol

D10AX02

Forms & Strengths

Topical cream 2%
Topical ointment 2%
Topical lotion 2%
Combined topical preparations (e.g., with sulfur)

Adult Dosing

Acne vulgaris: Apply thinly to affected areas 1 to 2 times daily
Seborrheic dermatitis: Apply to affected scalp or skin areas as directed
Hyperkeratotic conditions: Apply to affected areas 1 to 2 times daily

Pediatric Dosing

Adolescents (12 years and older): Apply thinly to affected areas 1 to 2 times daily, similar to adult dosing
Children under 12 years: Safety and efficacy not well established; use with extreme caution due to systemic absorption risks

Indications

Acne vulgaris
Seborrheic dermatitis
Eczema
Psoriasis
Other hyperkeratotic skin disorders

Mechanism of Action

Acts as a keratolytic agent by breaking down keratin and promoting shedding of the outer layer of the epidermis
Exhibits mild antiseptic, antibacterial, and antifungal properties
Has antipruritic effects on inflamed skin

Contraindications

Hypersensitivity to resorcinol or any component of the formulation
Application to broken, denuded, or acutely inflamed skin
Use on large surface areas in infants due to risk of systemic toxicity (methemoglobinemia, central nervous system toxicity)

Adverse Reactions

Local skin irritation, dryness, and redness
Pruritus and stinging at the application site
Excessive peeling or scaling
Darkening of light hair (when applied near the scalp)
Systemic toxicity with excessive absorption (methemoglobinemia, CNS depression, sweating, tachycardia)

Drug Interactions

Concomitant topical keratolytic or abrasive agents (e.g., benzoyl peroxide, tretinoin, salicylic acid) may cause cumulative skin irritation
Other topical medications that cause systemic absorption should be used cautiously to avoid additive toxicity

Curated Content: Needs Vetting Before Put to Clinical Use