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DERMATOLOGICALS › ANTI-ACNE PREPARATIONS › ANTI-ACNE PREPARATIONS FOR TOPICAL USE › Other anti-acne preparations for topical use
dapsone
D10AX05
Forms & Strengths
- Tablet: 25mg, 50mg, 100mg
- Gel: 5% (50mg/g)
- Topical: 5% gel
Adult Dosing
- Dermatitis herpetiformis: 50-100mg oral daily
- Leprosy: 50-100mg oral daily
- Pneumocystis jiroveci pneumonia prophylaxis: 50-100mg oral daily
- Acne: apply topical 5% gel once daily
Pediatric Dosing
- Dermatitis herpetiformis: 1-2mg/kg oral daily (max 50mg)
- Leprosy: 1-2mg/kg oral daily (max 50mg)
- Pneumocystis jiroveci pneumonia prophylaxis: 1-2mg/kg oral daily (max 50mg)
- Safety and efficacy of topical not established in pediatric patients under 12 years
Indications
- Dermatitis herpetiformis
- Leprosy
- Pneumocystis jiroveci pneumonia prophylaxis
- Acne vulgaris
- Brown recluse spider bite
Mechanism of Action
- Antimicrobial and anti-inflammatory properties
- Interferes with dihydrofolate synthase
- Inhibits bacterial synthesis of dihydrofolic acid
Contraindications
- Hypersensitivity to dapsone
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Adverse Reactions
- Hemolytic anemia
- Agranulocytosis
- Methemoglobinemia
- Rash
- Headache
- Nausea and vomiting
- Dizziness
- Insomnia
Drug Interactions
- Rifampicin: increased risk of hematologic toxicity
- Trimethoprim/sulfamethoxazole: increased risk of hematologic toxicity
- Folate antagonists: decreased efficacy of dapsone
- Methemoglobin-inducing agents: increased risk of methemoglobinemia
- CYP3A4 inhibitors: increased dapsone levels
Curated Content: Needs Vetting Before Put to Clinical Use