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DERMATOLOGICALS › OTHER DERMATOLOGICAL PREPARATIONS › OTHER DERMATOLOGICAL PREPARATIONS › Agents for dermatitis, excluding corticosteroids
pimecrolimus
D11AH02
Forms & Strengths
- Topical cream 1%
- Available in 15g, 30g, and 60g tubes
Adult Dosing
- Apply a thin layer to affected area twice daily
- Use for short-term and intermittent long-term therapy
Pediatric Dosing
- Apply a thin layer to affected area twice daily for children over 2 years
- Not recommended for children under 2 years
Indications
- Treatment of mild to moderate atopic dermatitis
- Treatment of facial and neck atopic dermatitis
Mechanism of Action
- Pimecrolimus is a topical calcineurin inhibitor
- Inhibits T-cell activation and cytokine release
- Reduces inflammation and pruritus
Contraindications
- Hypersensitivity to pimecrolimus or any component of the cream
- Children under 2 years due to potential risk of immunosuppression
Adverse Reactions
- Common: headache, influenza, pharyngitis, cough, application site reactions
- Less common: allergic reactions, skin burning, herpes simplex, folliculitis
Drug Interactions
- Avoid concomitant use with oral calcineurin inhibitors
- Cautious use with CYP3A4 inhibitors, as pimecrolimus is metabolized by this enzyme
Curated Content: Needs Vetting Before Put to Clinical Use