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DERMATOLOGICALS › OTHER DERMATOLOGICAL PREPARATIONS › OTHER DERMATOLOGICAL PREPARATIONS › Agents for dermatitis, excluding corticosteroids
alitretinoin
D11AH04
Forms & Strengths
- 0.1% gel
- Topical formulation
Adult Dosing
- Apply thinly to affected areas, 2-3 times a day
- Response to treatment should be assessed after 3-4 months
Pediatric Dosing
- Not recommended for children under 18 years
- Safety and efficacy have not been established
Indications
- Treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma
- Treatment of severe recalcitrant chronic hand eczema unresponsive to potent topical corticosteroids
Mechanism of Action
- Retinoid with immunomodulating and antiproliferative effects
- Inhibits keratinocyte proliferation and normalizes keratinocyte differentiation
Contraindications
- Hypersensitivity to alitretinoin or other retinoids
- Pregnancy and lactation
Adverse Reactions
- Skin irritation, redness, and itching
- Pain and inflammation at application site
- Rash, dermatitis, and skin infections
Drug Interactions
- Enhanced effects when used with other topical products containing retinoids or retinoic acid
- Concomitant use with other immunomodulators not recommended
Curated Content: Needs Vetting Before Put to Clinical Use