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DERMATOLOGICALS › OTHER DERMATOLOGICAL PREPARATIONS › OTHER DERMATOLOGICAL PREPARATIONS › Agents for dermatitis, excluding corticosteroids
crisaborole
D11AH06
Forms & Strengths
- 2% topical ointment
- 60g and 100g tubes
Adult Dosing
- apply a thin layer to affected areas twice daily
- use for up to 4 weeks for flare prevention
Pediatric Dosing
- apply a thin layer to affected areas twice daily for children 3 months and older
- safe use in children under 3 months not established
Indications
- mild to moderate atopic dermatitis
- treatment of mild to moderate eczema
Mechanism of Action
- selective inhibitor of phosphodiesterase 4
- reduces pro-inflammatory cytokines
Contraindications
- hypersensitivity to crisaborole or any component
- none known beyond hypersensitivity
Adverse Reactions
- most common: application site pain (3.6%) and exfoliation (2.7%)
- less common: nasopharyngitis, headache, and diarrhea
- severe reactions: may include hypersensitivity reactions
Drug Interactions
- none well-documented with concomitant topical use
Curated Content: Needs Vetting Before Put to Clinical Use