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mequinol

D11AX06

Forms & Strengths

2% and 5% topical cream
2% and 5% topical solution
combination products with tretinoin

Adult Dosing

apply to affected areas 2-3 times daily
do not exceed 2% concentration for facial skin
do not exceed 5% concentration for non-facial skin

Pediatric Dosing

limited data in pediatric patients under 12 years
avoid use in children under 12 years due to lack of data
same dosing as adults for patients 12 years and older

Indications

treatment of solar lentigines
treatment of ephelides
treatment of melasma
skin hyperpigmentation disorders

Mechanism of Action

tyrosinase inhibition
competitive inhibition of dihydroxyphenylalanine (DOPA) oxidase
reduction of melanin production

Contraindications

hypersensitivity to mequinol or any component
history of vitiligo or other depigmentation disorders

Adverse Reactions

skin irritation
erythema
dryness
pruritus
hypopigmentation

Drug Interactions

increased risk of skin irritation with concurrent use of other skin products
avoid concurrent use with benzoyl peroxide or other oxidizing agents

Curated Content: Needs Vetting Before Put to Clinical Use