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DERMATOLOGICALS › OTHER DERMATOLOGICAL PREPARATIONS › OTHER DERMATOLOGICAL PREPARATIONS › Other dermatologicals
diclofenac
D11AX18
Forms & Strengths
- Tablets: 25mg, 50mg, 75mg
- Delayed-release tablets: 25mg, 50mg, 75mg
- Extended-release tablets: 100mg
- Topical gel: 1% (10mg/g)
- Topical solution: 1.5% (15mg/mL)
Adult Dosing
- Osteoarthritis: 100-150mg/day in 2-3 divided doses
- Rheumatoid arthritis: 150-200mg/day in 3-4 divided doses
- Ankylosing spondylitis: 100-125mg/day in 2-3 divided doses
- Acute pain: 25-50mg every 8-12 hours as needed
Pediatric Dosing
- Juvenile rheumatoid arthritis: 0.5-2mg/kg/day in 2-3 divided doses, not to exceed 4mg/kg/day
- Safety and efficacy not established in patients < 2 years
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Acute pain
- Primary dysmenorrhea
- Juvenile rheumatoid arthritis
Mechanism of Action
- Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor
- Inhibits prostaglandin synthesis, reducing inflammation and pain
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- History of asthma or urticaria with NSAID use
- Pregnancy (third trimester) and lactation
- Severe hepatic or renal impairment
Adverse Reactions
- Gastrointestinal: nausea, vomiting, dyspepsia, abdominal pain
- Cardiovascular: hypertension, edema, increased risk of heart attack and stroke
- Renal: decreased renal function, acute kidney injury
- Hepatic: elevated liver enzymes, liver injury (rare)
- Dermatologic: rash, pruritus, photosensitivity
Drug Interactions
- Warfarin: increased anticoagulant effect
- Aspirin: increased risk of gastrointestinal toxicity
- Diuretics: reduced diuretic efficacy and increased risk of renal impairment
- Lithium: increased lithium levels and toxicity
- Methotrexate: increased methotrexate levels and toxicity
Curated Content: Needs Vetting Before Put to Clinical Use