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DERMATOLOGICALS › OTHER DERMATOLOGICAL PREPARATIONS › OTHER DERMATOLOGICAL PREPARATIONS › Other dermatologicals
brimonidine
D11AX21
Forms & Strengths
- Ophthalmic Solution: 0.1%, 0.15%, 0.2%
- Topical Gel: 0.33%
Adult Dosing
- Open-angle glaucoma or ocular hypertension: 1 drop in affected eye(s) TID approximately 8 hours apart (0.2% solution) or BID (0.15% or 0.1% solution)
- Persistent facial erythema of rosacea: Apply a pea-sized amount once daily to each of the five areas of the face (forehead, chin, nose, each cheek)
Pediatric Dosing
- Safety and efficacy not established in pediatric patients under 2 years of age for ophthalmic use
- Not recommended for pediatric patients under 18 years of age for topical dermatologic use due to risk of serious CNS depression
Indications
- Reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension
- Topical treatment of persistent facial erythema associated with rosacea in adults
Mechanism of Action
- Selective alpha-2 adrenergic receptor agonist
- Reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow
- Reduces facial erythema through direct vasoconstriction of cutaneous blood vessels
Contraindications
- Hypersensitivity to brimonidine tartrate or any component of the formulation
- Neonates and infants under 2 years of age (ophthalmic use)
- Concurrent use with monoamine oxidase (MAO) inhibitors
Adverse Reactions
- Ocular: Allergic conjunctivitis, conjunctival hyperemia, burning, stinging, pruritus, blurred vision, ocular dryness
- Systemic: Dry mouth, fatigue, somnolence, headache, dizziness, hypotension
- Topical dermatologic: Flushing, skin burning, contact dermatitis, erythema at application site
Drug Interactions
- MAO inhibitors: May theoretically affect catecholamine uptake and utilization; contraindicated
- CNS depressants (alcohol, barbiturates, opioids, sedatives, anesthetics): Potential additive CNS depressant effects
- Antihypertensives and cardiac glycosides: May result in additive effects on blood pressure or heart rate
Curated Content: Needs Vetting Before Put to Clinical Use