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hydrogen peroxide

D11AX25

Forms & Strengths

Solution 3%
Solution 1.5%
Concentrate 30%

Adult Dosing

Minor skin wounds: Apply 3% solution topically as needed for cleansing or debridement
Oral rinse: Dilute 3% solution with equal parts water, rinse for up to 1 minute, use up to 4 times daily

Pediatric Dosing

Children >2 years: Minor skin wounds, apply 3% solution topically as needed
Oral rinse in children >12 years: Dilute 3% solution 1:1 with water, up to 4 times daily

Indications

Cleansing of minor cuts, scrapes, and abrasions
Oral debriding agent for minor mouth irritations and gingivitis

Mechanism of Action

Acts as a topical anti-infective and debriding agent through the release of nascent oxygen
Produces effervescence upon contact with catalase in tissues, mechanically loosening debris and necrotic tissue
Exerts weak and transient bactericidal activity against bacteria, viruses, yeasts, and spores

Contraindications

Hypersensitivity to hydrogen peroxide
Do not use in deep body cavities or closed spaces without egress due to risk of gas embolism
Not for ophthalmic use

Adverse Reactions

Local irritation, stinging, or burning at application site
Tissue damage or delayed wound healing with prolonged or high-concentration use
Gas embolism or emphysema when trapped in closed body cavities
Oral mucosal irritation or hyperkeratosis with long-term mouthwash use

Drug Interactions

Inactivated by reducing agents, organic matter, and alkaline environments
May degrade or interfere with other topical antiseptics or enzymatic debriders when applied simultaneously

Curated Content: Needs Vetting Before Put to Clinical Use