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GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Antibiotics
amphotericin B
G01AA03
Forms & Strengths
- injection 50mg/vial
- lipid complex injection 5mg/mL
- liposomal injection 5mg/mL
Adult Dosing
- 0.25-1.0 mg/kg/day IV for 6-8 weeks
- 3-5 mg/kg/day liposomal IV for 6-8 weeks
- 2.5-5 mg/kg/day lipid complex IV for 6-8 weeks
Pediatric Dosing
- 0.25-1.0 mg/kg/day IV for 6-8 weeks, for children >1 month
- 3-5 mg/kg/day liposomal IV for 6-8 weeks, for children >1 month
- 2.5-5 mg/kg/day lipid complex IV for 6-8 weeks, for children >1 month
Indications
- invasive aspergillosis
- invasive candidiasis
- cryptococcosis
- histoplasmosis
- mucormycosis
Mechanism of Action
- binds to ergosterol in fungal cell membranes
- forms pores, allowing ions to escape
- disrupts cell membrane integrity, causing cell death
Contraindications
- hypersensitivity to amphotericin B or its components
- severe renal impairment, unless benefits outweigh risks
Adverse Reactions
- infusion-related reactions (fever, chills, rigors)
- nephrotoxicity
- hypokalemia
- hypomagnesemia
- anaphylaxis
Drug Interactions
- digoxin, increased risk of digitalis toxicity
- corticosteroids, increased risk of hypokalemia
- nephrotoxic agents (e.g., cyclosporine, aminoglycosides), increased risk of nephrotoxicity
Curated Content: Needs Vetting Before Put to Clinical Use