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GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Antibiotics
chloramphenicol
G01AA05
Forms & Strengths
- Capsules: 250mg
- Suspension: 150mg/5mL
- Injection: 1g/vial
Adult Dosing
- 500mg q6h for severe infections
- 250mg q6h for mild to moderate infections
- Maximum dose: 4g/day
Pediatric Dosing
- 50-100mg/kg/day, divided q6h
- Neonates: 25mg/kg/day, divided q6h
Indications
- Typhoid fever
- Bacteremia
- Meningitis
- Infections caused by H. influenzae
Mechanism of Action
- Inhibits protein synthesis by binding to 50S ribosomal subunit
- Bacteriostatic at low concentrations, bactericidal at high concentrations
Contraindications
- Hypersensitivity to chloramphenicol
- Bone marrow depression
- Porphyria
Adverse Reactions
- Bone marrow suppression
- Aplastic anemia
- Gray baby syndrome
- Gastrointestinal disturbances
Drug Interactions
- Interacts with oral hypoglycemics, increasing risk of hypoglycemia
- Enhances toxicity of vincristine and other bone marrow suppressants
Curated Content: Needs Vetting Before Put to Clinical Use